@presentation{klein_emc_24,
address = {Copenhagen, Denmark},
type = {Conference {Poster}},
title = {The apoptosome in situ},
author = {Klein, Calvin and Borgeaud, Alicia and Wozny, Michael R. and Lemmin, Thomas and Kukulski, Wanda},
month = aug,
year = {2024},
note = {EMC 2024 - Received Best Poster Prize},
}
@article{hossain_molecular_2021,
title = {Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases},
volume = {2021},
issn = {1942-0994, 1942-0900},
url = {https://www.hindawi.com/journals/omcl/2021/6621292/},
doi = {10.1155/2021/6621292},
abstract = {The mammalian cytosolic thioredoxin (Trx) system consists of Trx1 and its reductase...},
language = {en},
urldate = {2022-03-28},
journal = {Oxidative Medicine and Cellular Longevity},
author = {Hossain, Md Faruq and Bodnar, Yana and Klein, Calvin and Salas, Clara Ortegón and Arnér, Elias S. J. and Gellert, Manuela and Lillig, Christopher Horst},
editor = {Tejero, Jesús},
month = jun,
year = {2021},
pages = {1-17},
}
@mastersthesis{klein_characterization_2021,
address = {Bern},
title = {Characterization of a Thymidine Phosphorylase for Syntheses of Orphan Nucleoside Analogs},
url = {https://ck-biochem.com/download/MSc_Thesis_Calvin_Klein.pdf},
language = {English},
school = {University of Bern},
author = {Klein, Calvin},
month = sep,
year = {2021},
}
@bachelorsthesis{klein_electrostatic_2019,
address = {Greifswald},
type = {Bachelor Thesis},
url = {https://ck-biochem.com/download/BSc_Thesis_Calvin_Klein.pdf},
title = {Electrostatic Interactions between Human Trx and TrxR},
language = {English},
school = {University of Greifswald},
author = {Klein, Calvin},
month = aug,
year = {2019},
}
@presentation{hossain_predicting_2018,
address = {Berlin},
type = {Conference Poster},
title = {Predicting functions of Trx family proteins from primary structure - a first model.},
author = {Hossain, Md Faruq and Klein, Calvin and Mohamad, Heba and Lillig, Christopher H},
month = sep,
year = {2018},
note = {Meeting of the SPP1710/Study group redox biology of the GBM},
}
@presentation{hossain_what_2019,
address = {Newcastle, England},
type = {Conference {Poster}},
title = {What determines the substrate specificity of a protein?},
author = {Hossain, Md Faruq and Klein, Calvin and Berens, Felix and Bruhn, Lukas Willy and Liebscher, Volkmar and Helm, Christiane A. and Gellert, Manuela and Lillig, Christopher H},
month = jul,
year = {2019},
note = {A joint Biochemical Society and BSRA Scientific Conference},
}
@article{benitez-mateos_novel_2022,
title = {A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow},
issn = {2044-4761},
url = {https://pubs.rsc.org/en/content/articlelanding/2022/cy/d2cy00751g},
doi = {10.1039/D2CY00751G},
abstract = {Four pharmaceutically relevant nucleoside analogues (5-fluoro-2’-deoxyuridine, 5-chloro-2’-deoxyuridine, 5-bromo-2’-deoxyuridine, and 5-iodo-2’-deoxyuridine) have been synthesized by using a novel thymidine phosphorylase from H. elongata (HeTP). Following enzyme immobilization on microbeads, the biocatalyst was implemented as a packed-bed reactor for the continuous production of halogenated nucleosides, achieving up to 90\% conversion at the 10 mM scale with 30 min residence time. Taking the synthesis of Floxuridine (5-fluoro-2’-deoxyuridine) as study case, we obtained the highest space-time yield (5.5 g/L/h) reported to date. In addition, bioinformatic tools such as MD analysis and CapiPy have contributed to shine light on the catalytic performance of HeTP as well as its immobilization, respectively.},
language = {en},
urldate = {2022-08-30},
journal = {Catalysis Science and Technology},
author = {Benitez-Mateos, Ana I. and Klein, Calvin and Roura Padrosa, David and Paradisi, Francesca},
month = aug,
year = {2022},
pages = {-},
note = {Publisher: The Royal Society of Chemistry},
}
